Notes on Pollan, The Botany of desire

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The Botany of Desire: A Plant’s-Eye View of the World
Pollan, Michael
Citation (Chicago Style): Pollan, Michael. The Botany of Desire: A Plant’s-Eye View of the World. Random House Publishing Group, 2001. Kindle edition.

Introduction
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All those plants care about is what every being cares about on the most basic genetic level: making more copies of itself.
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Design in nature is but a concatenation of accidents, culled by natural selection until the result is so beautiful or effective as to seem a miracle of purpose.
Chapter 1
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Apples were something people drank. The reason people in Brilliant wanted John Chapman to stay and plant a nursery was the same reason he would soon be welcome in every cabin in Ohio: Johnny Appleseed was bringing the gift of alcohol to the frontier.
Chapter 3
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These ingredients would be combined in a hempseed-oil-based “flying ointment” that the witches would then administer vaginally using a special dildo. This was the “broomstick” by which these women were said to travel.
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(ethnobotanists call them “entheogens,” meaning “the god within”)
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The literary critic David Lenson, for one, believes it was crucial. He argues that Samuel Taylor Coleridge’s notion of the imagination as a mental faculty that “dissolves, diffuses, dissipates, in order to re-create,” an idea whose reverberations in Western culture haven’t yet been stilled, simply cannot be understood without reference to the change in consciousness wrought by opium.
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‘dissolution, diffusion and dissipation’
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One of the things certain drugs do to our perceptions is to distance or estrange the objects around us, aestheticizing the most commonplace things until they appear as ideal versions of themselves. Under the spell of cannabis “every object stands more clearly for all of its class,” as David Lenson writes in On Drugs. “A cup ‘looks like’ the Platonic Idea of a cup, a landscape looks like a landscape painting, a hamburger stands for all the trillions of hamburgers ever served, and so forth.” A psychoactive plant can open a door onto a world of archetypal forms,
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Allen Ginsberg suggested that the negative feelings marijuana sometimes provokes, such as anxiety, fear, and paranoia, are “traceable to the effects on consciousness not of the narcotic but of the law.”
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Taking account of this phenomenon, Andrew Weil describes marijuana as an “active placebo.”
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In 1988 Allyn Howlett, a researcher at the St. Louis University Medical School, discovered a specific receptor for THC in the brain—a type of nerve cell that THC binds to like a molecular key in a lock, causing it to activate.
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The cannabinoid receptors Howlett found showed up in vast numbers all over the brain (as well as in the immune and reproductive systems), though they were clustered in regions responsible for the mental processes that marijuana is known to alter: the cerebral cortex (the locus of higher-order thought), the hippocampus (memory), the basal ganglia (movement), and the amygdala (emotions). Curiously, the one neurological address where cannabinoid receptors didn’t show up was in the brain stem, which regulates involuntary functions such as circulation and respiration.
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Raphael Mechoulam (working with a collaborator, William Devane) found it: the brain’s own endogenous cannabinoid. He named it “anandamide,” from the Sanskrit word for “inner bliss.”
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some of the various direct and indirect effects of cannabinoids: pain relief, loss of short-term memory, sedation, and mild cognitive impairment.
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The purpose of THC could be to protect cannabis plants from ultraviolet radiation; it seems that the higher the altitude at which cannabis grows, the more THC it produces. THC also exhibits antibiotic properties, suggesting a role in protecting cannabis from disease. Last, it’s possible that THC gives the cannabis plant a sophisticated defense against pests. Cannabinoid receptors have been found in animals as primitive as the hydra, and researchers expect to find them in insects. Conceivably, cannabis produces THC to discombobulate the insects (and higher herbivores) that prey on the plant; it might make a bug (or a buck or a rabbit) forget what it’s doing or where in the world it last saw that tasty plant.
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Ma, the ancient Chinese character for “hemp,” depicts a male and a female plant under a roof—cannabis inside the house of human culture.
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Cognitive dysfunction?
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The scientists I spoke to were unanimous in citing short-term memory loss as one of the key neurological effects of the cannabinoids.
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All talk about the difficulty of reconstructing what happened mere seconds ago and what a Herculean challenge it becomes to follow the thread of a conversation (or a passage of prose) when one’s short-term memory isn’t operating normally.
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Yes, forgetting can be a curse, especially as we age. But forgetting is also one of the more important things healthy brains do, almost as important as remembering. Think how quickly the sheer volume and multiplicity of sensory information we receive every waking minute would overwhelm our consciousness if we couldn’t quickly forget a great deal more of it than we remember.
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“If we could hear the squirrel’s heartbeat, the sound of the grass growing, we should die of that roar,” George Eliot once wrote.
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The first part of Nietzsche’s essay is a moving and occasionally hilarious paean to the virtues of forgetting, which he maintains is a prerequisite to human happiness, mental health, and action.
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Like the American transcendentalists, Nietzsche believes that our personal and collective inheritance stands in the way of our enjoyment of life and accomplishment of anything original.
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My lawyer father, once complimented on his ability to see ahead three or four moves in a negotiation, explained that the reason he liked to jump to conclusions was so he could get there early and rest. I’m the same way in my negotiations with reality.
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Colors,” in classical rhetoric, are tropes.)
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Sagan, who was convinced that marijuana’s morning-after problem is not a question of self-deception so much as a failure to communicate—to put “these insights in a form acceptable to the quite different self that we are when we’re down the next day.”
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Memory is the enemy of wonder, which abides nowhere else but in the present. This is why, unless you are a child, wonder depends on forgetting—on a process, that is, of subtraction. Ordinarily we think of drug experiences as additive—it’s often said that drugs “distort” normal perceptions and augment the data of the senses (adding hallucinations, say), but it may be that the very opposite is true—that they work by subtracting some of the filters that consciousness normally interposes between us and the world.
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From a brain’s point of view, the distinction between a natural and an artificial high may be meaningless.

Hippocampus

Remapping revisited: how the hippocampus represents different spaces

André A. Fenton

Nature Reviews Neuroscience  volume 25, pages 428–448 (2024

  https://www.nature.com/articles/s41583-024-00817-x

Yassa, M.A., Stark, C.E.L. (2011) Pattern separation and the hippocampus. Trends in Neuroscience 34(10):515-525

Leal, S.L., Yassa, M.A. (2015) Neurocognitive aging and the hippocampus across species. Trends in Neurosciences 38(12): 800–812.

UC Irvine – Faculty Profile System

Remission from addiction: erasing the wrong circuits or making new ones? – Nature Reviews Neuroscience

 Time, Space and Memory  in the Hippocampal Formation, Derdikman et al.

This will come to you out of the blue. 

I am a 79 yo who retired in 2009 as Dean of Arts at uOttawa. I am also a PwP. Hence my interest in your lecture, which I shall attend with my wife, Nasrin Rahimieh, Associate Dean of Humanities for Academic Personal.

As a (concerned) amateur, I have been reading much popular neuroscience of late, including Erich Kandel, In Search of Memory; Linder,  The Accidental  Mind; MacDermott, 101 Theory Drive; and Brahic, The Power of Prions.

Also, I’ve written a blog piece on what happens when you have classic Parkinson’s, which I link here for what it’s worth: https://alteritas.net/GXL/?p=5189.

Could you suggest an article or two I should read before attending the Feb 4 lecture? I would be much obliged. 

George Lang 

THC and ECS

THC  

https://pmc.ncbi.nlm.nih.gov/articles/PMC6223748/ >>

THC elicits striatal DA release by activating CB1R, which are co-localized with DA receptors in the striatum and substantia nigra, regions implicated in salience processing (Wijayendran et al. 2016). This suggests that the endocannabinoid system (eCS) is involved in regulating DA release during salience attribution (Bloomfield et al. 2016), and that acute THC dysregulates the dopaminergic and endocannabinoid systems which then leads to impairments in salience processing (Wijayendran et al. 2016). These preclinical findings may provide a biological basis for human studies which show impaired salience processing after THC administration. In one study

As described in the Koob and Volkow model (2016), most drugs of abuse result in the hyperactivation of the mesocorticolimbic dopaminergic reward pathway in the binge-intoxication stage of addiction. This hyperactivation seems to be present in cannabis addiction but to a lower extent. Acute THC administration elicits striatal DA release in animals (Bloomfield et al. 2016) and THC challenges were shown to increase striatal DA transmission in humans (Stokes et al. 2010; Bossong et al. 2015); although other studies have found no THC-induced increases in striatal DA (Barkus et al. 2011; Urban et al. 2012). Additionally, there are no baseline differences in dopamine D2/D3 receptor availability between cannabis users and healthy controls (Volkow et al. 2014c; van de Giessen et al. 2017), a finding that does not parallel addiction to other drugs of abuse (including cocaine, alcohol, methamphetamine, nicotine, or heroin) which is associated with substantial reductions in D2R availability in the ventral striatum (Wang et al. 1997; Volkow et al. 2001, 2014c, 2017c; Martinez et al. 2012; Albrecht et al. 2013; Tomasi et al. 2015a; Wiers et al. 2016a; Ashok et al. 2017)

  

In addition, chronic cannabis use has been linked to impaired memory and IQ,suggesting changes in executive functioning after chronic cannabis use. However, IQ deficits appear to be present before initiation of cannabis use which may suggest that lower IQ could be a risk factor for cannabis addiction (Jackson et al. 2016).

 

 cannabis use disorder (CUD)

Dopamine = DA

https://www.apa.org/monitor/2023/06/marijuana-effects-brain

<< 

Researchers at the University of Colorado also found evidence that cannabis may be beneficial for older adults who start using later in life. MRI data showed that users had stronger connectivity than nonusers between parts of the brain that are important for cognitive functions, such as working memory and coordination (Watson, K. K., et al., Frontiers in Aging Neuroscience, Vol. 14, 2022). “Cannabis use could be offsetting normal age-related cognitive decline,” said Rachel Thayer, PhD, an assistant professor of neuropsychology at the University of Colorado, Colorado Springs.

 https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/abs/female-sex-as-a-protective-factor-in-the-effects-of-chronic-cannabis-use-on-verbal-learning-and-memory/437D670F390B4A96B05888FBDFB85C46

 Conclusions:

Results suggest that chronic cannabis use differentially impacts males and females, with females exhibiting better verbal learning and memory despite males demonstrating better attention and cognitive flexibility. Further research is needed to understand the potential protective mechanism of female sex on learning and memory effects of cannabis use.

  

https://www.apa.org/monitor/2015/11/marijuana-brain >>   Also immature in teens is the endocannabinoid system. As its name implies, this system  comprises the physiological mechanisms that respond to THC. That system is important for cognition, neurodevelopment, stress response and emotional control, and it helps to modulate other major neurotransmitter systems, says Krista Lisdahl, PhD, director of the Brain Imaging and Neuropsychology Laboratory at the University of Wisconsin, Milwaukee

Wiki endocannabinoids https://en.wikipedia.org/wiki/Endocannabinoid_system >>

Endocannabinoids are similar to the cannabinoids present in the cannabis sativa (C. sativa) plant. However, the human body naturally produces endocannabinoids. The term “endo” refers to “within,” as in within the body.

example, in rodents, the highest concentration of cannabinoid binding sites are in the basal ganglia and cerebellum, regions of the brain involved in the initiation and coordination of movement.[29] In humans, cannabinoid receptors exist in much lower concentration in these regions, which helps explain why cannabinoids possess a greater efficacy in altering rodent motor movements than they do in humans.

Mice treated with tetrahydrocannabinol (THC) show suppression of long-term potentiation in the hippocampus, a process that is essential for the formation and storage of long-term memory.[52] These results may concur with anecdotal evidence suggesting that smoking cannabis impairs short-term memory.[53] Consistent with this finding, mice without the CB1 receptor show enhanced memory and long-term potentiation indicating that the endocannabinoid system may play a pivotal role in the extinction of old memories?

In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity.[1] Since memories are postulated to be represented by vastly interconnected neural circuits in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (see Hebbian theory).

Evidence for the role of the endocannabinoid system in food-seeking behavior comes from a variety of cannabinoid studies. Emerging data suggests that THC acts via CB1 receptors in the hypothalamic nuclei to directly increase appetite.[59

In considering the efficacy of cannabis-based products, there remains controversy surrounding a concept termed “the entourage effect”. This concept describes a widely reported but poorly-understood synergistic effect of certain cannabinoids when phytocannabinoids are coadministered with other naturally-occurring chemical compounds in the cannabis plant (e.g., flavonoids, terpenoids, alkaloids). This entourage effect is often cited to explain the superior efficacy observed in some studies of whole-plant-derived cannabis therapeutics as compared to isolated or synthesized individual cannabis constituents.[14]

 https://en.m.wikipedia.org/wiki/Portal:Cannabis

 https://www.healthline.com/health/endocannabinoid-system#functions <<

Today, experts believe that maintaining homeostasis if the primary role of the ECS.

https://www.mdpi.com/1422-0067/19/3/833

https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569

<To stimulate these receptors, our bodies produce molecules called endocannabinoids, which have a structural similarity to molecules in the cannabis plant. The first endocannabinoid that was discovered was named anandamide after the Sanskrit word ananda for bliss. All of us have tiny cannabis-like molecules floating around in our brains. The cannabis plant, which humans have been using for about 5,000 years, essentially works its effect by hijacking this ancient cellular machinery

https://pmc.ncbi.nlm.nih.gov/articles/PMC6513728/  

< According to the popular writer Michael Pollan in his bestselling book The Botany of Desire, cannabis is one of the plants that humans have cultivated, or co-evolved with, for thousands of years. This is in part, Pollan writes, because the act of forgetting plays a valuable role in the ability of our brains to function without being overloaded with data from our senses that we are continually bombarded with. Pollan hypothesizes that if we didn’t forget, we wouldn’t function, and cannabis helps us do this. The role that the ECS plays in forgetting also opens up opportunities for the treatment of PTSD, a condition in which there are unpleasant, intrusive memories that people can’t help but remember, and that cause a whole syndrome of troublesome and dangerous symptoms related to the pathological remembering.

The ECS regulates and controls many of our most critical bodily functions such as learning and memory, emotional processing, sleep, temperature control, pain control, inflammatory and immune responses, and eating.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6513728/

   

Thoracic spine 

Thoracic spine

https://youtu.be/effXAxgxXb0?si=i4yefP1NjGG7Ky

https://youtu.be/effXAxgxXb0?si=gWQ9W4S_LjIXrLWq

Polonium effects?

Neurological effects of cannabis

Cannabinoids as neurotransmitters

Vivvagerne S2 E 5-6. In 2009 cellphones were still relatively new and were  actually used to communicate with other humans, as opposed to surfing or trolling

🔥🔥🔥🔥🔥   💦🔥🔥🔥🔥  

🔥🔥🔥💦💦  💦💦💦🔥🔥

🔥💦💦💦💦   💦💦💦💦💦

💦💦💦💦💦   💦💦💦💦 🔥  

🔥🔥💦💦💦  💦💦  🔥🔥🔥

🔥🔥🔥🔥💦   🔥🔥🔥🔥🔥

From the Pictograph to the Metapoem

#|cats of instar to why does purr rhyme with fur 

Disconsolant vs inconsolant

Memories has a different burden of connotations then memory alone. “Memories” “memory

< Xiǎo hóng shū   

很棒的吃饭地点

Hěn bàng de chīfàn dìdiǎn

18.01.202

#palindromo  :

O “Veludo azul”

Sem life, voa-nos diva de trama a amar-te. 

David só não vê filmes.

Luz a odu* levo

#palindromo

*odu

s.m. (iorubá) destino

很棒的吃饭地点

Lifeless, the diva of the plot flies to us loving you.
David just doesn’t watch movies.
I bring light to odu*

*odu s.m. (Yoruba) destiny

One positive effect of Parky is that I now must try to be conscious of what came automatically unconsciously before.

https://www.instagram.com/p/CRF2C2ggA0A/?igsh=MWQ1ZGUxMzBkMA== 

Davo on the squeeze box

I can’t speak jazz but I can understand, it esp the bebop of my generation.  Bbop coincided with beat generation. This is ancient I know

Carmen mcrae

Sonny clark voodoo

The poetry of jazz song titles 

Terra firma Irma, Joe Gordan

20.01.2025

Drachtzieher string puller

    spent a quarter century in  Edmonton

Snow in Houston

گرگ

Notes on Linden, The Accidental Mind

The Accidental Mind: How Brain Evolution Has Given Us Love, Memory, Dreams, and God
Linden, David J.
Citation (Chicago Style): Linden, David J.. The Accidental Mind: How Brain Evolution Has Given Us Love, Memory, Dreams, and God. Harvard University Press, 2012. Kindle edition.

One. The Inelegant Design of the Brain
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After much careful scientific thought, this master hormone was given the compelling name “growth hormone releasing hormone” (endocrinologists, like many scientists, are not known for their literary flair).
Two. Building a Brain with Yesterday’s Parts
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Glutamate and GABA are fast-acting neurotransmitters: when they bind their receptors, the electrical changes they produce occur within a few milliseconds. They are the dominant fast neurotransmitters in brain, but there are some other fast ones.
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quintessentially American
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solution: burn that junk in the front yard. For example, acetylcholine is destroyed in the synaptic cleft by an enzyme specifically built for that purpose. Most other neurotransmitters get the European treatment: they are recycled.
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whole trip will have been in vain, and no neurotransmitters will be released. What a bum deal! These constraints may have been tolerable for the simple problems solved by the nervous system of a worm or a jellyfish, but for the human brain, the constraints imposed by (ancient) neuronal electrical function are considerable.
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wiring of the brain is guided by patterns of activity, which allows the strength and pattern of synaptic connections to be molded by experience, a process called synaptic plasticity
Three. Some Assembly Required
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In other words, genes influence general intelligence but to a lesser degree than they influence personality.
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Sense of humor is another. Identical twins raised apart tend not to find the same things humorous, whereas they do share a sense of humor with their adoptive siblings.
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Proteins form the important structural and functional units of the cell. For example, they make all of the important neuronal molecules discussed so far. These include ion channels (such as the voltage-sensitive sodium channels that underlie the upstroke of the spike), enzymes that direct chemical reactions to produce or break down neurotransmitters (like the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine), and neurotransmitter receptors (such as glutamate receptors), as well as the structural molecules, the cables, tubes, and rods of protein that give neurons their shape.
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“homeotic” genes that are master regulators of early development. Homeotic genes code for proteins, and these proteins are,
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aberrant neuronal migration can result in cerebral palsy, mental retardation, and epilepsy.
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result supports the former model, in which developing neurons are derived from multipotent progenitors.
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This finding supports the latter model, in which neuronal fate is determined by cell lineage.
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In the case of humans, the period when brain wiring affects fine-scale brain development starts in the later stages of pregnancy and continues through the first few years of life.
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Strong activation of a synapse not only preserves and strengthens it, but also makes its neighbors weaker and ultimately can cause them to be eliminated. I’ll talk a lot about the molecular basis of how this happens in Chapter 5, when I consider memory storage that reuses these same mechanisms.
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“selectionist theory” or “neural Darwinism.”
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The ability of the brain to be modulated by experience is called neural plasticity.
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Rather than showing that extra enrichment beyond normal experience can boost brain growth, what this experiment shows is that severe environmental deprivation can, at least temporarily, cause a reduction in the complexity of cortical circuits.
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The flip side of this phenomenon is that babies exposed to two languages can develop perfectly accented speech in both languages.
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This is what can happen when a tiny bit of science finds it way into a policy debate.
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Learning is a process by which new experiences are integrated with previous experiences. Therefore, early experience may be important, not because it is written into neural circuitry more effectively, but rather because it is the basis for subsequent learning.
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Four. Sensation and Emotion
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the sensory world, our brains are messing with the data.
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Milder cases of this can involve inability to recognize a particular object within a class—the inability to pick out one’s own car in a full parking lot is typical.
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These neurons with a dual sensory and motor function were called mirror neurons.
Five. Learning, Memory, and Human Individuality
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modulatory neurotransmitter dopamine.
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This may explain why schizophrenics and patients with Parkinson’s disease, people whose ailments are associated with defects in dopamine signaling, perform poorly on tests of working memory.
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his splendid book The Seven Sins of Memory, the Harvard University psychologist Daniel Schacter speaks of three of these “sins of commission” in declarative memory retrieval: misattribution, suggestibility, and bias.
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if a particular pattern of neuronal activity results in a lasting modification of, say, voltage-sensitive sodium channels located at the axon hillock, such that the threshold for firing a spike was moved closer to the resting potential, then this could produce a lasting change in the firing properties of that neuron, thereby contributing to an engram. This is only one of many possible changes that would affect neuronal spiking. For example, modifying the voltage-sensitive potassium channels that underlie the downstroke of the spike could change their average time to open. This would result in alterations to the rate and number of spikes fired in response to synaptic drive. Indeed, changes in voltage-sensitive ion channels can persistently alter the intrinsic excitability of neurons and, in animal experiments, these changes can be triggered by learning.
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Experience-dependent modification of synaptic function is a general mechanism that is thought by most brain researchers to underlie a large part of memory storage.
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a microscopic level, the synapses of the brain are not static. They grow, shrink, morph, die off, and are newly born, and this structural dynamism is likely to be central to memory storage.
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In the years that followed, thousands of papers were published about LTP. One of the most interesting things scientists learned is that, although LTP was initially found in the hippocampus, it is actually a phenomenon that occurs throughout the brain.
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This is the ultimate example of “when life gives you lemons, make lemonade.” Our memory, which is the substrate of our consciousness and individuality, is nothing more than the accidental product of a work-around solution to a set of early evolutionary constraints. Put another way, our very humanness is the product of accidental design, constrained by evolution.
Six. Love and Sex
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In our modern world, some very recent changes relevant to sexual behavior, such as the availability of contraception and assisted fertility, and changes in social conventions, political systems, and technologies, have allowed women to live independently. Most of these changes have only appeared in the last generation. So, the genes that help to instruct the parts of our brains involved in sexual behavior have not yet undergone selection by many of the forces operating in modern society.
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lordosis, a posture that presents the genitals.
Seven. Sleeping and Dreaming
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memory has been nicely articulated by Robert Stickgold of the Harvard Medical School, who writes “the unique physiology of sleep and perhaps even more so, of REM sleep, shifts the brain/ mind into an altered state in which it pulls together disparate, often emotionally charged and weakly associated memories into a narrative structure and . . . this process of memory reactivation and association is, in fact, also a process of memory consolidation and integration that enhances our ability to function in the world.”
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Eight. The Religious Impulse
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Confabulation in anterograde amnesia is not a process under voluntary control. Rather, it’s what the brain does when confronted with a problem it cannot begin to solve: it makes a story from whatever bits of experience it can dredge up, in much the same way that narrative dreams are created from scraps of memory.
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Holiness the Dalai Lama has said, “If science proves Buddhism is wrong, then Buddhism must change.”
Nine. The Unintelligent Design of the Brain
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“Intelligent design readily embraces the sacramental nature of physical reality. Indeed, intelligent design is just the Logos theology of John’s Gospel restated in the idiom of information theory”
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which codes for a protein in the mitotic spindle (a structure used to organize the chromosomes during cell division), seems to determine how many times cortical progenitor cells divide before they become committed to becoming cortical neurons. As a result, this gene is crucial for determining cortical size.
Epilogue. That Middle Thing
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first glance, this would appear to be a fairly complete explanation, but it’s not. What’s missing is that middle thing. How is it that changing the strength of some synapses in the hippocampal circuit actually gives rise to memories for facts and events, as recalled during behavior?