geoplotsadmin – Page 9 – Stories on Myself

I’d read that there was a large .. err .. migration of Brazilians from Twitter to Bluesky. Here is an anagram you may have to use some program or another on.

Bolsonaro is a Brazilian Trump.

Looking forward to the day when the sun will return to this country.

Giba Assis Brasil (@gibaab.bsky.social)

Chucho Valdes: ‘Briyumba Palo Congo’

Nkisi Malongo

¿Quieres saber qué es briyumba congo? Apréndelo aquí – Conozcamos Todas Las Mitologias De Nuestro Planeta

Briyumba Palo Congo

22/02/2025

More on PD

Parkinson’s Disease: Gene Therapies

Calcium channel blocker

When more than 20 mg of simvastatin, a lipid-lowering agent, are given with amlodipine, the risk of myopathy increases.[40] The FDA issued a warning to limit simvastatin to a maximum dose of 20 mg if taken with amlodipine based on evidence from the SEARCH trial.[41] Giving amlodipine with Viagra increases the risk of hypotension.[7][10 < wiki amlodipine

The prion hypothesis suggests that alpha-synuclein aggregates are pathogenic and can spread to neighboring, healthy neurons and seed new aggregates. Some propose that the heterogeneity of PD may stem from different “strains” of alpha-synuclein aggregates and varying anatomical sites of origin

The incidence rate of falls in Parkinson’s patients is approximately 45 to 68%, thrice that of healthy individuals, and half of such falls result in serious secondary injuries. Falls increase morbidity and mortality.[227]Around 90% of those with PD develop hypokinetic dysarthria, which worsens with disease progression and can hinder communication.[228]Additionally, over 80%

of PD patients develop dysphagia: consequent inhalation of gastric and oropharyngeal secretions can lead to aspiration pneumonia.[229] Aspiration pneumonia is responsible for 70% of deaths in those with PD.[230]

< wiki

Dysarthria is a speech sound disorder resulting from neurological injury of the motor component of the motor–speech system[1] and is characterized by poor articulation of phonemes.[2] It is a condition in which problems effectively occur with the muscles that help produce speech, often making it very difficult to pronounce words

For instance, English philosopher Thomas Hobbes was diagnosed with “shaking palsy”—assumed to have been Parkinson’s—but continued writing works such as Leviathan.[289][290][291] Adolf Hitler is widely believed to have had Parkinson’s, and the condition may have influenced his decision making.[292][293][294] Mao Zedong was also reported to have died from the disorder.[295]

https://en.wikipedia.org/wiki/Gene_therapy_in_Parkinson%27s_disease

https://en.wikipedia.org/wiki/Cell-based_therapies_for_Parkinson%27s_disease

https://en.wikipedia.org/wiki/Management_of_Parkinson%27s_disease#

https://en.m.wikipedia.org/wiki/Hypernasal_speech

The new treatments for PD are in clinical trials and most of them are centered on gene therapy. With this, researchers expect to compensate the loss of dopamine or to protect the dopamine neurons from degeneration.[2] The pharmacological and surgical therapies for PD focus on compensating the ganglia dysfunction caused by the degeneration of the dopaminergic neuron from substantia nigra

As the gut microbiome in PD is often disrupted and produces toxic compounds, fecal microbiota transplants might restore a healthy microbiome and alleviate various motor and non-motor symptoms.[300] Neurotrophic factors—peptides that enhance the growth, maturation, and survival of neurons—show modest results but require invasive surgical administration. Viral vectors may represent a more feasible delivery platform.[304] Calcium channel blockers may be restore the calcium imbalance present in Parkinson’s, and are being investigated as a neuroprotective treatment.[305] Other therapies, like deferiprone, may reduce the abnormal accumulation of iron in PD.[305]

22/02/2025

The older you get the righter

The older you get the righter the binary Cartesian vision of body and soul seems. Tied to a dying carcass… increasingly it seems that the inversecof happening, a dying mind attached to a living carcass ….

Naturally, phenomenology and neuroscience find a convergence of common interests. However, primarily because of ontological disagreements between phenomenology and philosophy of mind, the dialogue between these two disciplines is still a very controversial subject.[9]

Husserl himself was very critical towards any attempt to “naturalizing” philosophy, and his phenomenology was founded upon a criticism of empiricism, “psychologism“, and “anthropologism” as contradictory standpoints in philosophy and logic.[10][11] The influential critique of the ontological assumptions of computationalist and representationalist cognitive science, as well as artificial intelligence, made by philosopher Hubert Dreyfus has marked new directions for integration of neurosciences with an embodied ontology.

The work of Dreyfus has influenced cognitive scientists and neuroscientists to study phenomenology and embodied cognitive science and/or enactivism. One such case is neuroscientist Walter Freeman, whose neurodynamical analysis has a marked Merleau-Pontyian approach.[12]

Wiki Dreyfus < Knowing-how and knowing-that. Research in psychology and economics has been able to show that Dreyfus’ (and Heidegger’s) speculation about the nature of human problem solving was essentially correct. Daniel Kahnemann and Amos Tversky collected a vast amount of hard evidence that human beings use two very different methods to solve problems, which they named “system 1” and “system 2”. System one, also known as the adaptive unconscious, is fast, intuitive and unconscious. System 2 is slow, logical and deliberate.

“Walter J. Freeman III”. Nonlinear Dynamics in Psychology. 21/4. 2017

Abstracts-Neurodynamics-Freeman

Unclear Nuclear

Two poems transposed into verse: Pastis plus Giraffes

Been thinking of Ovid of late

Alles ist mir Treppenwitz.

It’s liking sinking into your own past, coming to terms with death, unclear

About

Before someone more than weighs the nuclear

Option

Serpant en fr. English?

Chaplinesque : this was an unattainable ideal model for me. Anyone else feel the same?

A Defense of Wishy-washy Liberalism

The music in European TV series