PD research ot UCI

 

Clinical Review of Smartphone Applications in Parkinson’s Disease – PubMed

Convention vs. innovation III: The promise of stem cell therapy in Parkinson’s disease remains bright (PSG debate 2024) – PubMed

Convention vs. innovation II: Genetic profiles should be a standard consideration in the assessment for deep brain stimulation candidacy for people with Parkinson’s disease (PSG debate 2024) – PubMed

   

Subtype I, comprised of 60 patients (~58.3%), was characterized by mild symptoms, both motor and non-motor.

< Abstract of  https://pubmed.ncbi.nlm.nih.gov/34535682/

 https://pubmed.ncbi.nlm.nih.gov/33545080/    < Stem cells

Freezing of gait in parkinsonian syndromes is a disabling motor block described by patients as having their feet stuck to the floor leading to difficulty in initiation of gait and increased risk for falls. Wearable assistive devices such as Google Glass™ use visual and auditory cueing that may improve gait pattern in patients with freezing of gait. Augmented reality programs using wearable assistive devices are a home-based therapy, with the potential for reinforcing physical therapy techniques 

< https://pubmed.ncbi.nlm.nih.gov/33216658/          

https://pubmed.ncbi.nlm.nih.gov/37974260/

https://pubmed.ncbi.nlm.nih.gov/33463754/

 Current strategies to manage FOG include pharmacological interventions, physiotherapy, brain surgery (including deep brain stimulation/DBS) and cueing.<    https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/s12938-023-01167

FoG and Freezing

FoG in PD overload

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144986#sec020  

Subtypes

https://jamanetwork.com/journals/jamaneurology/article-abstract/1827554

Goal directed vs habitual control in the BG

https://pubmed.ncbi.nlm.nih.gov/20944662/

https://en.m.wikipedia.org/wiki/u

It is clear that other neurotransmitters than DA play a role in the pathophysiology of PD (Bohnen et al., 2018; Braak et al., 2004; Delaville et al., 2012; Faggiani and Benazzouz, 2017; Fornai et al., 2007; Pahapill and Lozano, 2000; Politis et al., 2014). Yet, non-DA therapeutic strategies are still difficult to develop (Fox, 2013; Freitas and Fox, 2016). It is likely that the lack of neurocognitive footing in clinical neuroimaging studies does not help for distinguishing the neural mechanisms that rely on DA neurotransmission from those that rely on other systems. We especially think about the noradrenergic system, which might be involved in the functioning of BG-thalamo-cortical loops and executive functions (Albares et al., 2015b; Chamberlain et al., 2009; Faggiani and Benazzouz, 2017; Spay et al., 2018), but also about the serotoninergic (Carli and Invernizzi, 2014; Miguelez et al., 2014) and the cholinergic (Bohnen and Albin, 2011) systems.

https://neurotoolkit.com/updrs/

Criaud and collaborators (2016b) proposed that  akinesia …, an executive function which supports the gating of movement triggering to avoid inappropriate or premature responses in runcertain context (Jahanshahi et al., 2015a; 2015b). According to this view, akinesia could be considered as a de-automation symptom resulting partly from an impairment of the ability to switch from controlled to automatic action (Albares et al., 2015b; Favre et al., 2013; Hikosaka and Isoda, 2010; Isoda and Hikosaka, 2007; Jahanshahi et al., 1995; Jahanshahi et al., 2015a; 2015b; Siegert et al., 2002)

Restoration and targeting of aberrant neurotransmitters in Parkinson’s disease therapeutics

https://www.sciencedirect.com/science/article/abs/pii/S0197018622000523

https://en.m.wikipedia.org/wiki/Abulia

  

 

Parkinson Disease Can Be Viewed in Part as a Failure to Select Sensorimotor Options 

The cardinal symptoms of Parkinson disease are akinesia (difficulties in initiating movement), bradykinesia (initiated movements are slow), and rigidity (stiffness and resistance to passive movement). Tremor is often but not always present. The principal neurological deficit responsible for the motor symptoms of Parkinson disease is thought to be the progressive degeneration of dopaminergic neurotransmission in the basal ganglia.

 A consequence of this loss of dopamine is increased tonic and oscillatory activity in the recordings from basal ganglia output nuclei. Since the output of the basal ganglia is GABAergic and inhibitory, in Parkinson disease, targeted structures are receiving high and uneven levels of inhibitory input. This condition impairs the normal selective (disinhibitory) function of the basal ganglia; movements are difficult to select and, when possible, are slow to execute. 

Parkinson disease is, however, more nuanced than this. Over much of this progressive condition, the loss of dopaminergic transmission differentially affects the sensorimotor territories of the basal ganglia, leaving the limbic and associative territories comparatively unaffected. As discussed in the section on goal-directed and habitual control, the sensorimotor territories of the basal ganglia play an essential role in selecting habitual actions. Perhaps, therefore, it is not surprising that many of the motor features of Parkinson disease can be interpreted in terms of a loss of automatic habits. While patients can do things, they are trapped in the slower, serial, and voluntary mode of goal-directed control.

  

  

FoG and Freezing

FoG in PD overload

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144986#sec020  

Subtypes

https://jamanetwork.com/journals/jamaneurology/article-abstract/1827554

Goal directed vs habitual control in the BG

https://pubmed.ncbi.nlm.nih.gov/20944662/

https://en.m.wikipedia.org/wiki/u

It is clear that other neurotransmitters than DA play a role in the pathophysiology of PD (Bohnen et al., 2018; Braak et al., 2004; Delaville et al., 2012; Faggiani and Benazzouz, 2017; Fornai et al., 2007; Pahapill and Lozano, 2000; Politis et al., 2014). Yet, non-DA therapeutic strategies are still difficult to develop (Fox, 2013; Freitas and Fox, 2016). It is likely that the lack of neurocognitive footing in clinical neuroimaging studies does not help for distinguishing the neural mechanisms that rely on DA neurotransmission from those that rely on other systems. We especially think about the noradrenergic system, which might be involved in the functioning of BG-thalamo-cortical loops and executive functions (Albares et al., 2015b; Chamberlain et al., 2009; Faggiani and Benazzouz, 2017; Spay et al., 2018), but also about the serotoninergic (Carli and Invernizzi, 2014; Miguelez et al., 2014) and the cholinergic (Bohnen and Albin, 2011) systems.

https://neurotoolkit.com/updrs/

Criaud and collaborators (2016b) proposed that  akinesia …, an executive function which supports the gating of movement triggering to avoid inappropriate or premature responses in runcertain context (Jahanshahi et al., 2015a; 2015b). According to this view, akinesia could be considered as a de-automation symptom resulting partly from an impairment of the ability to switch from controlled to automatic action (Albares et al., 2015b; Favre et al., 2013; Hikosaka and Isoda, 2010; Isoda and Hikosaka, 2007; Jahanshahi et al., 1995; Jahanshahi et al., 2015a; 2015b; Siegert et al., 2002)

Restoration and targeting of aberrant neurotransmitters in Parkinson’s disease therapeutics

https://www.sciencedirect.com/science/article/abs/pii/S0197018622000523

https://en.m.wikipedia.org/wiki/Abulia

  

 

Parkinson Disease Can Be Viewed in Part as a Failure to Select Sensorimotor Options 

The cardinal symptoms of Parkinson disease are akinesia (difficulties in initiating movement), bradykinesia (initiated movements are slow), and rigidity (stiffness and resistance to passive movement). Tremor is often but not always present. The principal neurological deficit responsible for the motor symptoms of Parkinson disease is thought to be the progressive degeneration of dopaminergic neurotransmission in the basal ganglia.

 A consequence of this loss of dopamine is increased tonic and oscillatory activity in the recordings from basal ganglia output nuclei. Since the output of the basal ganglia is GABAergic and inhibitory, in Parkinson disease, targeted structures are receiving high and uneven levels of inhibitory input. This condition impairs the normal selective (disinhibitory) function of the basal ganglia; movements are difficult to select and, when possible, are slow to execute. 

Parkinson disease is, however, more nuanced than this. Over much of this progressive condition, the loss of dopaminergic transmission differentially affects the sensorimotor territories of the basal ganglia, leaving the limbic and associative territories comparatively unaffected. As discussed in the section on goal-directed and habitual control, the sensorimotor territories of the basal ganglia play an essential role in selecting habitual actions. Perhaps, therefore, it is not surprising that many of the motor features of Parkinson disease can be interpreted in terms of a loss of automatic habits. While patients can do things, they are trapped in the slower, serial, and voluntary mode of goal-directed control.

  

  

Estoy harto de los poetas norte-americanos

https://www.instagram.com/p/C4O6qy6P-3r/?igsh=NTc4MTIwNjQ2YQ==

Bellelettristic haibun

Innsbruck the gang of whatever

Rueful person

https://gem.cbc.ca/tribal/s02?cmp=DM_GemNewsletter_GEM_Tribal2_060225

Dept. Q is an adaptation of the novels of the same name by Danish author Jussi Adler-Olsen. The series revolves around Carl Morck, a former top-rated detective in

Edinburgh assigned to a new cold case whilst wracked with guilt following an attack that left his partner paralyzed and another police officer dead.

Ondas curtas

Part of me relishes Trump and MAGA, since in many regards it confirms what I thought the US was, growing up in the East End of Houston, though in relatively progressive working and lower middle class milieu. In the 50s Pasadena..Sinclair unionized park place elementary school was a traditional

For example, I remember in the second grade having been disappointed by the sudden  cancelation of the May Day pole dance …

I said progressive. At the same time it was separately white, as was all of Houston and the South …

It’s going to take a lot of courage to confront the forthcoming descent into barbarism, maybe to no avail. I hope and pray for the comng generations that it will be more like the 60s than the 30s. I say this  w/out any illusion .

It’s going to take a tremendous amount of courage.

Kugel. Sweet vs savoury.

Freewmanrle Yes Productions

What does aikido teach about resistance?

Windmills whoosh

Hollywood

He was always falling in love with actresses . I mean real ones.

Interrompti One  Isla mujeres

Two  :  Dream of Africa

Teaching is a drag. What’s fun is learning

Eugenie Grandet

I’ve never like the dasual usecofcthec ofcthe word toxic byr reunp isxic bur trump

They had operstions like others have children

For (and with) my cousin Red Dog
and in memory of Johnny, my Dad   

Prosopagnosiac Maniac

Poetry | The James Hearst Digital Archive

Poetry | The James Hearst Digital Archive

Alfredo got snagged on a floating tree and almost drowned.

Brouwer Nuevos estudios simples

https://x.com/victoriamoul/status/1915756996025897090?s=46&t=JS3op2cvLeWPj9dDLynbJg

Deux flics sur les docks

A less sociable introvert. I ve had a personality change …

She’s  not my step- rather my half-sister:  Halfsibling blood sibling

Move deliberately, like Otto the Potto, a slothful  nocturnal primate known in Liberia as a sodtly-softly.  Not really sloth-like, as you can see. But decidedly slothful.

Okay, okay, it’s getting harder and harder to resist. Uncle !  I give in. Yours’ll become the first podcast I subscribe to.

Meme les mauvaises sont bonnes, les mémoires et souvenirs, je veux dire.

CertaInes,  comment dirais-je, défaillances, ceux  toujours selement celle qui me connaǐt le meilleur, puissent

Des stupéfiants

Writing hmy preAdolecent years autotherappy

Emoji.   

Q zzz  va vs cv cg zzz fcc bc cc

Tho primarily a poet i do not eschew prose.

Tho i believe that consensus should be as broad as possible

 At least as i understand Canadians. Born in Fort Smith. Raised as an Irish Catholic in Edmonton. Thanking the team

Swear I can smell the rotting corpses of the termites next door. Where they this morning were untented after a three dsy fumigation

Follow   Victoria BC

Langs are systems whoch mrans that you must become systemaic to learn them  study them

Brands of Cig

Your litany of brands.

Would add to the list of delectable coffin nails I inhaled only Gauloises, unfiltered brun, later filtered and blond in red packs.  yellow-pack American Spirit, plus, I almost forgot, Luckles, Camels, English Ovals.

What a delight smoking once was.   

And back then brands offered

distinctive flavours and highs