PD and Diverticulitis

Based on the search results provided, there appears to be an association between colonic diverticular disease (CDD) and an increased risk of developing Parkinson’s disease (PD):

The first study12 found that the risk of Parkinson’s disease was 27% higher in the CDD cohort compared to the control group without CDD. Specifically, CDD patients aged 65 and older had a 1.25-fold increased risk of developing PD compared to those without CDD in the same age group.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9399652/

The proposed mechanisms linking CDD and PD risk include:14

  1. The abnormal accumulation of alpha-synuclein in enteric neurons, which causes autonomic dysfunction and gastrointestinal hypomotility, leading to the development of diverticula.
  2. The altered gut microbiome in PD patients, which can promote Lewy body pathology and intestinal inflammation, contributing to CDD.

In conclusion, the available evidence suggests that colonic diverticular disease may be associated with an increased risk of developing Parkinson’s disease. Patients with CDD should be monitored for signs of PD, as the risk of this neurodegenerative disorder appears to be higher in this population.12

      

Multidirectional associations between the gut microbiota and Parkinson’s disease, updated information from the perspectives of humoral pathway, cellular immune pathway and neuronal pathway.

 

https://pubmed.ncbi.nlm.nih.gov/37920444/

Three causes: 1) genetic, 2) environmental toxins and 3) gut malfunction, which, alas, just kicks the can down the road, since where does the gut malfunction come from.

  1. Mother had it. 
  1. I was raised in the East End of Houston, known for chemical affluents.
  1. Before my onset, I had diverticulitis, and was successfully operated on for it.

https://www.pacificneuroscienceinstitute.org/blog/parkinsons-disease/parkinsons-disease-and-the-gut/

https://www.pacificneuroscienceinstitute.org/blog/parkinsons-disease/parkinsons-disease-combating-constipation/

https://www.pacificneuroscienceinstitute.org/blog/parkinsons-disease/parkinsons-disease-understanding-the-gut-brain-connection/

 

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