Author: geoplotsadmin

Mighty interesting, this info.

Underlying question: is cancer a metabolic or genetic disease? 

But like most binaries, too simple. Viral or immunological?

Is Cancer a Genetic Disease or a Metabolic Disease?

Is Cancer a Genetic Disease or a Metabolic Disease?

https://pubmed.ncbi.nlm.nih.gov/28250801

Cancer is a systemic disease involving multiple time- and space-dependent changes in the health status of cells and tissues that ultimately lead to malignant tumors [2]. Neoplasia involving dysregulated cell growth is the biological endpoint of the disease [3, 4]. Tumor cell invasion into surrounding tissues and their spread (metastasis) to distant organs is the primary cause of morbidity and mortality…

Press pulse extinction modes and models

 

In contrast to the extensive genetic heterogeneity seen in tumors, most if not all neoplastic cells within tumors share the common metabolic malady of aerobic fermentation that arises ultimately from dysregulated oxidative phosphorylation [2, 17, 29–33]. In light of these findings, cancer can also be recognized as a metabolic disease.

https://www.nature.com/articles/s42003-019-0455-x#Fig2

 https://www.nature.com/articles/s42003-019-0455-x the lead article

In 1927 Otto Warburg noticed that cancer cells exhibited a distinct metabolic phenotype, consuming up to 200× more glucose than normal cells (the “Warburg effect”). Indeed, based on Warburg’s influence, most cancer drugs discovered in the 1950s and 1960s were called “antimetabolites”. However, with Warburg’s death in 1970 and the discovery of oncogenes in 1971, most cancer researchers shifted their thinking to view cancer as a genetic disease rather than a metabolic disease. 

Andrei: ever notice movie soundtracks?   

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer – PubMed

Targeting glutamine metabolism as a therapeutic strategy for cancer – Experimental & Molecular Medicine

DON

We’re Not “DON” Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine

Glutamine-Blocking Drug Slows Tumor Growth And Strengthens Anti-Tumor Response

Epstein–Barr virus at 60

Raffaele Di Giacomo, PhD (@sciqst) on X

‘Dramatic’ inroads against aggressive brain cancer— Harvard Gazette

I asked both Chat GPT and Grok the same question and got two very similar replies:  How do  drugs like levadopa get from the stomach to the part of the brain affected by Parkinson’s? How long does it take?

Chat GPT:

Levodopa, the primary medication used to treat Parkinson’s disease, is absorbed in the small intestine after being taken orally. Once absorbed, it enters the bloodstream and is transported to the brain where it is converted into dopamine, the neurotransmitter that is deficient in Parkinson’s patients. The time it takes for levodopa to reach the brain and start working can vary depending on factors such as the individual’s metabolism, the presence of food in the stomach, and other medications being taken concurrently. Generally, it can take around 30 minutes to 1 hour for levodopa to start having an effect, with peak levels reached within 1-2 hours after ingestion

GROK:
Drugs like levodopa, the primary medication for Parkinson’s disease, are administered orally and absorbed in the small intestine. Once absorbed, levodopa is transported to the brain via the bloodstream. The drug then crosses the blood-brain barrier and reaches the affected areas of the brain, such as the substantia nigra, where it is converted into dopamine to help alleviate Parkinson’s symptoms.

The time it takes for levodopa to reach the brain and exert its effects can vary depending on factors such as individual absorption rates, food intake, and the presence of other medications. On average, it takes about 30 minutes to 1 hour for levodopa to be absorbed and reach peak levels in the bloodstream. However, the onset of symptom relief may vary from person to person.

It’s important to note that the effectiveness of levodopa can be influenced by various factors, such as the progression of the disease, the presence of other medications, and individual patient characteristics.

Will AI Replace Us? with Matt Ginsberg – StarTalk Radio | Podcast on Spotify :  Will AI Replace Us? with Matt Ginsberg

Vicarious  living 

SM strange congruence between Social media  and Sadomasochism.

Rimbaud , Camus,  Cioran  

Thr concept of check-and-balances applies far beyond the realm of govt

The geo ethnology of SE is trananational  everywhere as w

My self improvement hygiene regime includes chair yoga and studying, as olposed to learnibg let alone speaking fluently or not, Vietnamese.

I speak weird KV, for example I say things like Mô cuzin-ye subjtement arrivé.

Concrte rhetoric which i first proposed in 1979 

Kipling poem / Dad 

Je suis de nature furtive 

*

Personal reasons i’ve usually omitted from official academic justifications for my interest in creoles (our maid Casey and green-eyed creoles working in the Sinclair refinery in 1965inclait refinertym

Incidentally, it is not beyond the realm of posibility that i suffered from PD-causing toxins , having been raised in ehe East End of Houston. 

Stinky pots Simms bayou…

*

Personal reasons i’ve usually omitted from official academic justifications for my interest in creoles (our maid Casey and green-eyed creoles working in the Sinclair refinery in 1965inclait refinertym

Incidentally, it is not beyond the realm of posibility that i suffered from PD-causing toxins , having been raised in ehe East End of Houston. 

Stinky pots Simms bayou…

Moi aussi, je déteste le climat de Montréal  : plus précisément, je supporte mal l’été là-bas.     

Fusionnel

I once planned a book with a rather pretentious title, The Rhetoric of Polemic. It was going to have chapter on manifestos.   I even wrote and published one when I was FOTB in Montreal in the 70s, age 31. I mention these dates here and in general because

Copy to Wynia https://alteritas.net/GXL/?p=4514

Humans may well be the highest form of “intelligent life” in the conditions, so far, on Planet Earth. But, considering how aleatory those conditions were, you’d have to be blindly arrogant to pretend to have any idea what other intelligent forms elsewhere are like. 

Mo linm vyé portré-yé de Dragon Ball Z myé ké portré-yé apré moun saïya. Animasyon dan vyé portré-yé çé myé. Osi navé plis kung fu pa jist pouvwa

I prefer seeing old drawings of Dragon Ball Z over

I’ve started studying Vietnamese, which is not the same thing as learning it -> my personal history with Tieng viet)

The reverse prompt tries to determine precisely what the AI chat bot was prompted by . A bit like reverese Turing Test

Olney, at least when i knew him best. In the late sixties and early seventies, was above all a wonderful host…

Prognosis vs diagnosis

Not just superstition but genuine belief

Immunology

University exacts a heavy toll on those lucky enough to belong to this institution

Symptoms of a syndrome

*

Something of a connoisseur of cannabis chocolates

http://gferrater.blogspot.com/2011/01/joan-ferrate.html 

And thanks to @eblanes as well for a fascinating blog  of his 

own on my Doktorvater, Juan Ferrate, brother of Gabriel, http://gferrater.blogspot.com/2011/01/joan-ferrate.html   As he knows, I wrote affectionately about Juan in my memory piece Edmonton Is Fun After All:  https://alteritas.net/GXL/?page_id=2490

https://www.instagram.com/reel/C3A9-hsth3G/?  igsh=ZDE1MWVjZGVmZQ==   

< alzapua   

Michael Berryhill
Andrei Hershel
Tom Lane
Brian Ferguson
Robin Buck
Red Dog Young
Shervin Tag
Fritz Pöhl
Alfredo Pons
Louie Nosko
Paul Morris
André Lapierre
Eric Lueders

https://www.instagram.com/reel/C3GEJ1xiksu/?igsh=ZDE1MWVjZGVmZQ== omelette

Passau 

Apunts sobre G. Ferrater Perpinyà2022

Der Panther – Rilke

Alton Gisclair – premier char (family’s first car) – story in Bayou Lafourche French

https://www.instagram.com/reel/C1-8FcHL19q/?igsh=ZDE1MWVjZGVmZQ==

https://www.instagram.com/reel/C3kOh3SN8FI/?igsh=ZDE1MWVjZGVmZQ==

Bulerias

This rather pained poem dates from my Berkeley period, say 1982: https://alteritas.net/pastis/inventory/reciprocity/

It is interesting, to me at least, how sublimated my reaction was to what was obviously a debilitating experience. But that is often what poetry is for.

 

 

 

 

Il boutonne son trench.

Sortir mes documents sur RNW  

Kiffer
La famille a explosé
Cuistrot   –  clodaud
Picoler

Narcisse L’Heureux,
Pamphile Racine,
Marie-Québec née Marie-France,
Yves Pellerin\
Candide Pellerin
Gilles Arsenault
Jacinto Nascimento\
Christopher Marrow

Chouette
Et celle  des câlins
Un mismatch
Merci. Il y a un promo

Turn Contes montréalais into a thriller …

Portraits of the Dramatis personae

L’évolution actuelle du français

Dispendieux
Rester dans les clous
J’vais te dire un truc
Ado .
Paumé
Se pointer
Tu me ghostes
Smoking a cig
Il les degouille kills ghrm
Tu  le chopes

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