Carnet intime
Your litany of brands.
Would add to the list of delectable coffin nails I inhaled only Gauloises, unfiltered brun, later filtered and blond in red packs. yellow-pack American Spirit, plus, I almost forgot, Luckles, Camels, English Ovals.
What a delight smoking once was.
And back then brands offered
distinctive flavours and highs
Petrichor
Look up dyslexia wiki
National Institutes of Health
In those days, forty years ago, Kermit wrote all of it himselfs. I do find it amazing that they have created a recognizable house style.
Leonard Cohen – What Is Coming 2.16.03 |
Lyrics what is coming
In honour of Leo XIV, a member of the Augustinian Order, this link to the obit wrote for my prof Ted Blodgett.
I attended Ted’s CompLit seminar on Latin poetry in 1969. We read St Augustine, whose name I then mispronounced like that of the Southern lawn grass.
https://alteritas.net/GXL/wp-content/uploads/2023/06/A_Tribute_to_Ted_Blodgett-1.pdf
https://en.wikipedia.org/wiki/Psalms
https://en.wikipedia.org/wiki/Rule_of_Saint_Augustine
Schrapnel
Chaos and Creoles
Forensics
Stories on myself
https://alteritas.net/pastis/we-touch-from-afar/
What is a secretary of state? A guide to Mark Carney’s two-tiered cabinet
https://en.m.wikipedia.org/wiki/A_Canticle_for_Leibowitz
A stray reference to to A Canticle for Leibowitz, a 1959 post-apocalypse sci-fi novel, reminded me that I have not always been uninterested in genre-fiction. My old backyard buddy Michael B. and I read it avidly while in high school. Maybe, as a real apocalypse looms and bastions of learning are being threated, its time has come around again. Wiki it for a summary.
Wiki rasagiline
< Rasagiline is used to treat symptoms of Parkinson’s disease both alone and in combination with other drugs. It has shown efficacy in both early and advanced Parkinson’s, and appears to be especially useful in dealing with non-motor symptoms like fatigue.[15][16][2]
< MAO-B inhibitors like rasagiline may improve certain non-motor symptoms in Parkinson’s disease.[19] These may include depression, sleep disturbances, and pain (particularly related to motor fluctuations), but are unlikely to include cognitive or olfactory dysfunctions
< Parkinson’s disease is characterized by the death of cells that produce dopamine, a neurotransmitter. An enzyme called monoamine oxidase (MAO) breaks down neurotransmitters. MAO has two forms, MAO-A and MAO-B. MAO-B is involved in the metabolism of dopamine. Rasagiline prevents the breakdown of dopamine by irreversibly binding to MAO-B. Dopamine is therefore more available, somewhat compensating for the diminished quantities made in the brains of people with Parkinson’s disease.
< In 2021, it was discovered that MAO-A is solely or almost entirely responsible for striatal dopamine catabolism in the rodent brain and that MAO-B is not importantly involved.[70][71][72] In contrast, MAO-B appears to mediate tonic γ-aminobutyric acid (GABA) synthesis from putrescine in the striatum, a minor and alternative metabolic pathway of GABA synthesis, and this synthesized GABA in turn inhibits dopaminergic neurons in this brain area
< Like rasagiline, 1-aminoindan shows neuroprotective activity in some experimental models.[1][56] In addition, 1-aminoindan has been found to enhance striatal dopaminergicneurotransmission and improve motor function independent of MAO inhibition in animal models of Parkinson’s disease.
< Rasagiline has been found to bind reversibly to α-synuclein, a major protein involved in the pathophysiology of Parkinson’s disease, and this action might be neuroprotective.[82][83][84]
< Pahwa and Lyons
Rascol O, Fitzer-Attas CJ, Hauser R, et al. A double-blind, delayed-start trial of rasagiline in Pasrkinson’s disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes. Lancet Neurol 2011; 10: 415–23.
Enzyme inhibitor https://en.wikipedia.org/wiki/Enzyme_inhibitor#Irreversible_inhibitors
Neural Control of Walking in People with Parkinsonism
We adhere to a use of the term akinesia restricted to dysfunctions of movement initiation, ranging from delayed response to freezing or even total abolition of movement < https://www.sciencedirect.com/topics/neuroscience/akinesia
Akinesia is just one side of the coin. Basal ganglia, selection control etc. By an actual patient
Was I Born a Parky? Or Did I Become One?
< Results reveal, however, that various abnormalities within but also outside the motor and dopaminergic pathways might be associated with akinesia in PD patients. Notably, numerous yet poorly reproducible neural correlates were found in different brain regions supporting executive control by means of resting-state or task-based studies.
> We adhere to a use of the term akinesia restricted to dysfunctions of movement initiation, ranging from delayed response to freezing or even total abolition of movement. We also call for targeting more specific neural mechanisms of movement preparation and action triggering with more sophisticated behavioral designs/event-related neurofunctional analyses.
Symptom and syndrome are two terms commonly used in medical contexts to describe different aspects of a patient’s condition. A symptom refers to a specific indication or manifestation of an underlying disease or disorder that is experienced by the patient. It is often subjective and can vary from person to person. On the other hand, a syndrome is a collection of symptoms that occur together and are characteristic of a particular medical condition. It is a more comprehensive term that encompasses multiple symptoms and provides a broader understanding of the overall clinical picture. While symptoms help identify the presence of a problem, syndromes aid in diagnosing and categorizing specific diseases or disorders.
< https://thisvsthat.io/symptom-vs-syndrome
Disease vs. Disorder: What Is the Difference?
Accumulating evidence suggests that nicotine, a drug that stimulates nicotinic acetylcholine receptors, may be of therapeutic value in Parkinson’s disease. Beneficial effects may be several-fold. One of these is a protective action against nigrostriatal damage. This possibility stems from the results of epidemiological studies that consistently demonstrate an inverse correlation between tobacco use and Parkinson’s disease. <
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.2190
Twins: By Mikael Häggström.When using this image in external works, it may be cited as:Häggström, Mikael (2014). “Medical gallery of Mikael Häggström 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.008. ISSN 2002-4436. Public Domain.orBy Mikael Häggström, used with permission. – Own work, CC0, https://commons.wikimedia.org/w/index.php?curid=33081803
Risk factors for seborrhoeic dermatitis include poor immune function, Parkinson’s disease, and alcoholic pancreatitis < wiki seborrhoeic dermatitis
https://en.wikipedia.org/wiki/Frenkel_exercises
Purkinjje cells
Goal vs habitual action:
https://pubmed.ncbi.nlm.nih.gov/20944662/
Abstract
Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson’s disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson’s disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.
Kreyol: https://www.instagram.com/reel/DH6ZI7Wx8s2/?igsh=NTc4MTIwNjQ2YQ==
I’ve never been very aural.
https://en.m.wikipedia.org/wiki/Coenzyme_Q10
发布了一篇小红书笔记，快来看吧！ 😆 LwfcR2WCFCX1OyO 😆 http://xhslink.com/a/gZnILyYqaJl9，复制本条信息，打开【小红书】App查看精彩内容！
89% 10 being among the verbiage English and I have a wee smattering of Mandarin.
Gitchy gitchy gou
2 Buddhawangwang发布了一篇小红书笔记，快来看吧！ 😆 C2nHN06nCvDW1uX 😆 http://xhslink.com/a/fUFHTkgXtGN9，复制本条信息，打开【小红书】App查看精彩内容！
https://alteritas.net/pastis/edge-2/ > tumblr
https://alteritas.net/pastis/edge-2/
https://alteritas.net/pastis/tag/satori/page/2/
https://alteritas.net/pastis/tag/satori/page/2/
Deja vu vs d.v. all over again
Sestina vs sonnet
Isla mulheres
I said proximity not propenquity
I was as close to a French existentialist as I could be in 1966, and moreover I was living in France. Not Paris, where l imagined every French person aspired to be, but in Grenoble.
I had the extravagant privilege of a third year abroad, it was a privilege I had had to fight. In fact, this dream year went back to my adolescence. Since the age of 16…
There is nothing I agree with Donald Trump about, but sometimes he happens to agree with me. Case in point: the fashion of imposing your personal choice of pronouns on anyone else.
Xi holds the best, actually the better cards in the game he’s playing wiith Trump
Edge
Find earlier cersion
Add line seasons keeping as second line
My Father … Dad’s course in life was fixed by his own father’s..
Liiterary but also digital
https://www.theatlantic.com/culture/archive/2020/04/20-undersung-crime-shows-to-watch-in-quarantine/610387/?gift=KKKlYTXEEqlHqE1fxXU8Y68BMZutsOXxLlnjhu7m_h4&utm_source=copy-link&utm_medium=social&utm_campaign=share
Blueberry soup
I’m not much for speculative fiction but was drawn into this book by its spurious use of neural science (the protag has two thalami) and by its topicality: violation of Canadian sovereignty, a rogue VP, the 25th Amendment. It finishes with a nuc… WAIT! NO SPOILERS!.
It was Good Friday so we took Sofie out for a fancy seafood meal. She’s the Mom of a good friend who has become a friend herself. She snapped the first shot, which I love. ThenI took the other two, the first while she was sending me the first one.
MAGA is to WOKE just as WOKE is to MAGA.