Author: geoplotsadmin

Cognitive science

https://en.m.wikipedia.org/wiki/Cognitive_science 

Even if the technology to map out every neuron in the brain in real-time were available and it were known when each neuron fired it would still be impossible to know how a particular firing of neurons translates into the observed behavior

There is some debate in the field as to whether the mind is best viewed as a huge array of small but individually feeble elements (i.e. neurons), or as a collection of higher-level structures such as symbols, schemes, plans, and rules. The former view uses connectionism to study the mind, whereas the latter emphasizes symbolic artificial intelligence. One way to view the issue is whether it is possible to accurately simulate a human brain on a computer without accurately simulating the neurons that make up the human brain.

  Research methods borrowed directly from neuroscience and neuropsychology can also help us to understand aspects of intelligence. These methods allow us to understand how intelligent behavior is implemented in a physical system.

• Single-unit recording
• Direct brain stimulation
• Animal models
• Postmortem studies  

https://en.m.wikipedia.org/wiki/Artificial_intelligence

https://en.m.wikipedia.org/wiki/Memory 

https://en.m.wikipedia.org/wiki/Cognitive_revolution

Steven Pinker claims that the cognitive revolution bridged the gap between the physical world and the world of ideas, concepts, meanings and intentions. It unified the two worlds with a theory that mental life can be explained in terms of information, computation and feedback.[8i

Cognitive science is actually a science of only one part of the mind, the part that has to do with thinking, reasoning, and intellect. It leaves emotions out. “And minds without emotions are not really minds at all…”[31]

The authors argue that connectionist models were closer to symbolic models than to neurobiology.[27]

Notes on Parky

parkinsons-treatment-29399.com

Hypokinesia

cParkinson’s disease

https://en.m.wikipedia.org/wiki/Swallowing

https://en.m.wikipedia.org/wiki/Parkinson%27s_disease_dementia

https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062

  >> Alpha-synuclein clumps are a hallmark sign of Parkinson’s disease. The test accurately identified people with Parkinson’s disease 87.7% of the time.  ..The test is called an alpha-synuclein seed amplification assay.

Levodopa, the most effective Parkinson’s disease medicine, is a natural chemical that passes into the brain and is converted to dopamine. 

Mayo Clinic specialists study genetics, diagnosis and treatment options for people with Parkinson’s disease and other movement disorders. You may have the opportunity to participate in research  studies and clinical

Watch Mayo Clinic neurologist J. Eric Ahlskog, M.D., Ph.D., describe Parkinson’s disease treatment on YouTube.

https://www.mayoclinic.org/drugs-supplements/carbidopa-and-levodopa-oral-route/before-using/drg-20095211    

https://en.wikipedia.org/wiki/Substantia_nigra

The substantia nigra is an important player in brain function, in particular, in eye movement, motor planning, reward-seeking, learning, and addiction.!!!!

Pars compacta /SNpc : Parkinson’s disease is characterized by the death of dopaminergic neurons in this region.[1]

There’s also Cannabinoidergic, or cannabinergic, means “working on the endocannabinoid neurotransmitters“. As with terms such as dopaminergic and serotonergic, related proteins and cellular components involved endocannabinoid signaling, such as the cannabinoid (CB1) receptor, as well as exogenous compounds, such as phytocannabinoids or other cannabinoids which modulate the activity of endocannabinoid system, can be described as cannabinoidergic.[1]

https://en.m.wikipedia.org/wiki/Basal_ganglia

Degeneration of pigmented neurons in this region [SN] is the principal pathology that underlies Parkinson’s disease and this depigmentation can be visualized in vivo with Neuromelanin MRI.[9] 

https://en.m.wikipedia.org/wiki/Cannabinoid

CBN is thought to interact with other kinds of neurotransmission (e.g., dopaminergic, serotonergic, cholinergic, and noradrenergic).

https://www.instagram.com/reel/CxONyjHrjDA/?igshid=MzRlODBiNWFlZA==

the current opinion in pharmacology is that dopamine instead confers motivational salience;[6][7][8] 

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.[1]

l-DOPA crosses the protective blood–brain barrier, whereas dopamine itself cannot.[7]  

To bypass these effects, it is standard clinical practice to coadminister (with l-DOPA) a peripheral DOPA decarboxylase inhibitor (DDCI) such as carbidopa (medicines containing carbidopa

In work that earned him a Nobel Prize in 2000, Swedish scientist Arvid Carlsson first showed in the 1950s that administering l-DOPA to animals with drug-induced (reserpine) Parkinsonian symptoms caused a reduction in the intensity of the animals’ symptoms. 

https://en.m.wikipedia.org/wiki/Neuropsychopharmacology

As a consequence, high levels of dopamine lead to high levels of motor activity and impulsive behavior; low levels of dopamine lead to torpor and slowed reactions.[50]

Recent advances have demonstrated that glial cells, specifically microglia and astroglia, are involved in several neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS), Epilepsy, Parkinson’s disease (PD), Alzheimer’s disease (AD), and ..

Neuromodulation of Glial Function During Neurodegeneration

Most people can’t see beyond their own language, let alone language itself.  / La plupart des gens ne peuvent pas voir au-delà de leur propre langue, encore moins de la langue elle-même. / Die meisten Menschen können nicht über ihre eigene Sprache hinaus sehen, geschweige denn über die Sprache selbst.

Language is a barrier to  … reality. But a permeable, sieve-like one. One analogy is the blood-brain barrier (BBB)5

Speaking of hobbies, I just realized I gave up aikido for neuroscience

I had slways looked at us as a species, certainly not a gift of (or to) God.

Rebels without a cause always appealed to me more than rebels with one .  I did try out causes, of course. Not surprisingly, they didn’t work out.

Thr rightwing / the left a bunch of  swarmy wimps. Who do you think will win?  

“Swarmy” is not from Yiddish but I swear I’ve heard it yiddishized into “schwarmy”.

Reading neuroscience is like reading a foreign language I’m not proficient at. I tend get the drift but miss words, esp the acronyms and names of chemicals. When these lapses accumulate to the point I don’t follow anymore, I have go back and work on my vocabulary. Practice makes perfect. [?’d on 25 Sep] 

Just as I was reading about the important roles sodium and potassium play in neurotransmission, I got a message from Kaiser showing that my test results for both of them, liver related, plus creatinine which is kidney related, are resolutely  normal. That is, Levadopa has not adversely affected my blood chemistry. Good news. [sms’d to nr 26 Sep]  

https://alteritas.net/pastis/headstone-2/  

Was I more psycho- than sociopath?
Hard to say. The twain do almost meet.
Cautiously, I trod the strait path
between, kept my missteps discreet.

Poetry is a tail trying to wag the dog of reality

Love weighs its price

I get vertigo when I think about my past life, and when I imagine the future lives  of those younger than I

The jargon of science ….

How much marijuana / cannabis / THC mangles elementary math. 

Austria is a delightfully alcoholic country but this does have unfortunate consequences

Ah age! When the seat of pleasure becomes source of pain.

Using my return to Montréal as a source of meditation abt my political stance then and now

Once I got over his hippie-like attachment to the idea of beards, a moment which ironically coincided with the physiologicsl  capacity of growing one.

What does it mean to be “born into”….

Sometimes an almost religious sense  of awe settles over me when I contemplate the neurological complexity of the brain, in which electrochemical machine consciousness is truly a ghost.  https://en.m.wikipedia.org/wiki/Ghost_in_the_machine  [X’d 1 Oct]

Putain becomes shit, shit fuck, in subtitled French.

[ X] is grateful to currently reside with his Anishinaabe husband in T’karonto (Toronto), the traditional lands and territory of many nations including the Mississaugas of the Credit, the Anishinaabeg, the Chippewa, the Haudenosaunee and the Wendat Peoples and now home to many diverse First Nations, Inuit and Métis Peoples..

Défaillance de l’âge

Son ocd? Compulsive disorder / trouble obsessionnel compulsifsfjgd kfc ,,,,

Add  mes adieux to Like a Log

https://www.instagram.com/reel/CxRHP0IybX1/?igshid=MzRlODBiNWFlZA==

Senility is the price of living for a long time.

Trans of … missing germanic words into poetry

Pic of Citroen

China practices capitalism with Chinese characteristics

Cog-wheeling

Things to do

Shots x 2

Toll Roads 9HLF989 JTMAB3FV9PD144636

2023 Toyota RAV4

Letter to Nancy Snyder

Dying in Africa to old Observ

All political lives, unless they are cut off in midstream at a happy juncture, end in failure….   < Enoch Powell

Jealousy implies rivalry, hence equality of contestants. To suffer from literary jealousy implies …   

etym of rival : [Latin rīvālis, one using the same stream as another, a rival, from rīvus, stream; see rei- get in Indo-mm

     

  

Mother always warned me about the Book-Fairies.
I held them in greater awe than even the Christian
God during the two brief phases in my life
When I lived in fear and trembling of Him.

A memorial  prosy-poem.

Based on true events.

https://www.instagram.com/reel/CwYbirvOxSf/?igshid=MzRlODBiNWFlZA==  cod in spocy miso sauce