Central and peripheral innate and adaptive immunity in Parkinson’s disease
> Instead, PD can be considered to be a chronic inflammatory systemic disease
Alpha synuclein potentially connects the gut-brain axis in Parkinson’s disease patients. Common inherited Parkinson disease is associated with mutations in the alpha-synuclein (SNCA) gene. In the process of seeded nucleation, alpha-synuclein acquires a cross-sheet structure similar to other amyloids. [27
< wiki alpha-synuclein
> Identification of RORγt+ MHCII+ antigen- presenting cells in the gut has raised the possibility of systemically regulating gut immune tolerance in early life to prevent or reduce the risk of PD development. …
We need to harness this information to identify those individuals at higher risk of PD because of their genetics, environmental exposures, and lifestyle choices, as well as individuals in the prodromal stages who could be treated with immunomodulatory interventions to delay, slow, or arrest progression of the disease from the periphery to the CNS.
Parkinsonism and carbon monoxide intox?
ChatGPT : Carbon monoxide poisoning and Parkinson’s disease both produce similar effects on the substantia nigra. Carbon monoxide is a toxic gas that can interfere with the normal functioning of the brain, including the substantia nigra. This region of the brain is responsible for producing dopamine, a neurotransmitter that plays a crucial role in movement and coordination. When the substantia nigra is damaged or affected, dopamine production is disrupted, leading to symptoms similar to those seen in Parkinson’s disease. These symptoms may include tremors, muscle stiffness, and difficulty with movement. While the causes of Parkinson’s disease are still not fully understood, carbon monoxide poisoning provides a clear example of how damage to the substantia nigra can result in similar effects.
Solvents and Parkinson disease: A systematic review of toxicological and epidemiological evidence
The Brain Lesion Responsible for Parkinsonism After Carbon Monoxide Poisoning
The Brain Lesion Responsible for Parkinsonism After Carbon Monoxide Poisoning
A partial list of famous people with Parkinson’s:
- Muhammad Ali, boxer (boxing-induced)
- Johnny Cash, singer
- Michael J. Fox, actor
- Estelle Getty, actress
- Billy Graham, evangelist
- Pauline Kael, film critic
- Deborah Kerr, actress
- Janet Reno, former U.S. Attorney General
- George Roy Hill, 81, director
- Michael Redgrave, 77, actor
- Pope John Paul II, 84, pope
- Terry-Thomas, 79, actor
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